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A study from the Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA shows that Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

This study was published in the 25 September issue of 2014 Nature Cell Biology (I.F: 20.085) by Prof. Kalluri R, Valerie S. LeBleu  [I.F > 20.058] and others from the University of Texas MD Anderson Cancer Center, Houston, Texas.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMDreports here that: Small Molecule-based anti-metastasis therapy: Rubone suppresses the expression of transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  and inhibits metastasis via up regulation of its target gene This study may suggest that Rubone, by up regulating its target gene, it may decrease the levels of  peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. Thereby, it may inhibit (1) oxidative phosphorylation; (2) mitochondrial biogenesis; and (3) oxygen consumption rate. Together, this study suggests that pharmacological formulations encompassing Rubone or its analogues can be used to inhibit invasion and metastasis of tumor cells.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., Small Molecule-based anti-metastasis therapy: Rubone suppresses the expression of transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  and inhibits metastasis via up regulation of its target gene, 9/October/2014, 14.13, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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