Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product-based therapy for Cancer: Phloretin decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation via up regulation of its target gene, 31/October/2014, 5.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: A mechanistic insight into how Phloretin decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation.
Significance: The result presented here suggests that Phloretin, by decreasing the expression of its target gene, it may decrease glutathione levels, increase reactive oxygen species levels and inhibit cancer cell proliferation. Thus, pharmacological formulations encompassing “Phloretin or its analogues” can be used to treat cancer.