Monthly Archives: November 2014

Therapeutic insights into increasing the life expectancy of Individuals: MiRNA-101 increases the expression of longevity-promoting gene Sirtuin-1 via down regulation of its target gene, 4/November/2014, 22.41

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into increasing the life expectancy of Individuals: MiRNA-101 increases the expression of longevity-promoting gene Sirtuin-1 via down regulation of its target gene, 4/November/2014, 22.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first … Continue reading

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Differentiation therapy for Cancer: CPEB1 increases the expression of tumor suppressor p53 via down regulation of its target gene, 4/November/2014, 22.32

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Differentiation therapy for Cancer: CPEB1 increases the expression of tumor suppressor p53 via down regulation of its target gene, 4/November/2014, 22.32,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org Significance: CPEB1, by … Continue reading

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Therapeutic insights into increasing the life expectancy of Individuals: Argonaute-2 (ago-2) increases the expression of longevity-promoting gene Sirtuin-1 via down regulation of its target gene, 4/November/2014, 22.20

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into increasing the life expectancy of Individuals: Argonaute-2 (ago-2) increases the expression of longevity-promoting gene Sirtuin-1 via down regulation of its target gene, 4/November/2014, 22.20, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first … Continue reading

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Molecular therapy for Cancer: NRF2 increases miRNA biogenesis and promotes tumor regression via up regulation of its target gene, 4/November/2014, 21.55

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Molecular therapy for Cancer: NRF2 increases miRNA biogenesis and promotes tumor regression via up regulation of its target gene, 4/November/2014, 21.55,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Becoming Centenarians: a myth or reality: The curcumin analogue EF24 may increase longevity via up regulation of autophagy enhancer Beclin-1, 4/November/2014, 21.00

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Becoming Centenarians: a myth or reality: The curcumin analogue EF24 may increase longevity via up regulation of autophagy enhancer Beclin-1, 4/November/2014, 21.00, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests  that EF24, by increasing the expression of … Continue reading

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Vitamin-based therapy for metastastic hepatocellular carcinoma: 1,25-dihydroxyvitamin D suppresses the expression of ICMT-Rac1 via up regulation of its target gene, 4/November/2014, 13.41

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Vitamin-based therapy for metastastic hepatocellular carcinoma: 1,25-dihydroxyvitamin D suppresses the expression of ICMT-Rac1 via up regulation of its target gene, 4/November/2014, 13.41,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Chemopreventive therapy against Human Cancer: Octanoate inhibits tumor cell proliferation via down regulation of Superoxide dismutase 1 (SOD1), 4/November/2014, 13.15

The 1989 Nobel prize winner in Physiology/Medicine Prof. Varmus Harold E, Somwar R and others from High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; and the US National Cancer Institute, USA has published a research paper in the 27 September 2011 issue of Proc Natl Acad Sci … Continue reading

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Therapeutic insights into the treatment of hypertension, endothelial dysfunction and cardiovascular diseases: SMAD7 promotes endothelium-dependent vasorelaxation via up regulation of its target gene, 4/November/2014, 13.09

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Therapeutic insights into the treatment of hypertension, endothelial dysfunction and cardiovascular diseases: SMAD7 promotes endothelium-dependent vasorelaxation via up regulation of its target gene, 4/November/2014, 13.09, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests, for the first time, … Continue reading

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Natural product-based therapy for Cancer: Fermented guava leaf extract increases the expression of the tumor suppressor tumor suppressor RECK via down regulation of its target gene, 4/November/2014, 13.05

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: Fermented guava leaf extract  increases the expression of the tumor suppressor tumor suppressor RECK via down regulation of its target gene, 4/November/2014, 13.05,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Molecular therapy for traumatic brain injury (TBI): Nitric oxide synthase activators alleviate apoptosis of neuronal cells after traumatic brain injury via up regulation of their target genes, 4/November/2014, 13.01

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Molecular therapy for traumatic brain injury (TBI): Nitric oxide synthase activators alleviate apoptosis of neuronal cells after traumatic brain injury via up regulation of their target genes, 4/November/2014, 13.01, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This … Continue reading

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Natural product-based therapy for Cancer: Garlic increases miRNA biogenesis and promotes tumor regression via up regulation of its target gene, 3/November/2014, 14.37

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Natural product-based therapy for Cancer: Garlic increases miRNA biogenesis and promotes tumor regression via up regulation of its target gene, 3/November/2014, 14.37,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Cytokine-based therapy for hypertension, endothelial dysfunction and cardiovascular diseases: IL-6 promotes endothelium-dependent vasorelaxation via up regulation of its target gene, 3/November/2014, 14.28

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Cytokine-based therapy for hypertension, endothelial dysfunction and cardiovascular diseases: IL-6 promotes endothelium-dependent vasorelaxation via up regulation of its target gene, 3/November/2014, 14.29, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests, for the first time, that IL-6, by decreasing … Continue reading

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Natural product-based therapy for Cancer: Fermented guava leaf extract increases the expression of the tumor suppressor tumor suppressor GRHL3 via down regulation of its target gene, 3/November/2014, 14.24

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: Fermented guava leaf extract  increases the expression of the tumor suppressor tumor suppressor GRHL3 via down regulation of its target gene, 3/November/2014, 14.23,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Natural product-based therapy for traumatic brain injury (TBI): An Estrogen derivative (17α-E2) alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 3/November/2014, 14.18

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Natural product-based therapy for traumatic brain injury (TBI): An Estrogen derivative (17α-E2) alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 3/November/2014, 14.18, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study … Continue reading

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Chemopreventive therapy against Human Cancer: Glucosamine-6-phosphate inhibits tumor cell proliferation via down regulation of Superoxide dismutase 1 (SOD1), 3/November/2014, 14.14

The 1989 Nobel prize winner in Physiology/Medicine Prof. Varmus Harold E, Somwar R and others from High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; and the US National Cancer Institute, USA has published a research paper in the 27 September 2011 issue of Proc Natl Acad Sci … Continue reading

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Natural product-based therapy for Myocardial Infarction: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 2/November/2014, 23.10

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural … Continue reading

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Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of stem cell protein Sox2 via up regulation of its target gene, 2/November/2014, 22.41

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, L., Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of stem cell protein Sox2 via up regulation of its target gene, 2/November/2014, 22.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests that Angiopoietin-like protein 1, by increasing the … Continue reading

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Therapeutic insights into increasing healthspan and life span: Germinated brown rice (GBR) inhibits the expression of pro-inflammatory protein tumor necrosis factor-α (TNFα), 2/November/2014, 22.37

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan Therapeutic insights into increasing healthspan and life span: Germinated brown rice (GBR) inhibits the expression of pro-inflammatory protein tumor necrosis factor-α (TNFα), 2/November/2014, 22.39,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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MiRNA-based therapy for Cancer: MiRNA-222 increases miRNA biogenesis and promotes tumor regression via down regulation of its target gene, 2/November/2014, 11.37 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  MiRNA-based therapy for Cancer: MiRNA-222 increases miRNA biogenesis and promotes tumor regression via down regulation of its target gene, 2/November/2014, 11.37 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Anti-miRNA based therapy for NIDDM: Increased expression of Stress-responsive miRNA-545 promotes gluconeogenesis and hyperglycemia via down regulation of Cyclin D1, 02/September/2014, 10.45 am

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department … Continue reading

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