Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, MiRNA-based therapy for Cancer: p53 up regulates the expression of tumor suppressor LKB1 through induction of its target miRNA, 1/November/2014, 8.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests that p53, by increasing the expression of its target miRNA, it may increase the expression of tumor suppressor LKB1. Thus, pharmacological formulations encompassing “p53 activators“ may be used to treat LKB1-mutated human tumors.
Undisclosed information: A mechanistic insight into how p53 increases the expression of LKB1.
Amount: $ 300
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