Monthly Archives: January 2015

Life-extention therapy for Males: Ankaflavin increases male longevity via up regulation of its target gene, 31/January/2014, 23.41

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Life-extention therapy for Males: Ankaflavin increases male longevity via up regulation of its target gene, 31/January/2014, 23.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests  that Ankaflavin, by increasing the expression of its target gene, it … Continue reading

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Mechanistic insight into tumorigenesis: Cluster of Differentiation-24 (CD-24) suppresses the expression of tumor suppressor IGFBP3 via down regulation of its target gene, 31/January/2015, 23.24

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorigenesis: Cluster of Differentiation-24 (CD-24) suppresses the expression of tumor suppressor IGFBP3 via down regulation of its target gene, 31/January/2015, 23.24, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first … Continue reading

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Mechanistic insight into tumorigenesis: Tudor Staphylococcal Nuclease protein suppresses the expression of tumor suppressor TIMP3 via down regulation of its target gene, 31/January/20145, 23.22

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorigenesis: Tudor Staphylococcal Nuclease protein suppresses the expression of tumor suppressor TIMP3 via down regulation of its target gene, 31/January/20145, 23.22, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, … Continue reading

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Natural product-based antimetastatic therapy: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresses the expression L1CAM via up regulation of its target gene, 31/January/20145, 23.07

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based antimetastatic therapy: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresses the expression L1CAM via up regulation of its target gene, 31/January/20145, 23.07, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first … Continue reading

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Preserving the function of the guardian of the genome, p53: Tumor suppressor ING1b inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 31/January/2015, 19.34

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Preserving the function of the guardian of the genome, p53:  Tumor suppressor ING1b inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 31/January/2015, 19.34, Genome-2-Bio-Medicine Discovery … Continue reading

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Natural product-based cancer therapy: Agaricus blazei Murill, a medicinal mushroom, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 31/January/2015, 19.28

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical … Continue reading

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Massage therapy for cancer patients: Massage attenuates inflammatory signalling-associated transformation and increases the expression of tumor suppressor Sprouty2 via down regulation of its target gene, 31/January/2015, 17.51

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Massage therapy for cancer patients: Massage attenuates inflammatory signalling-associated transformation and increases the expression of tumor suppressor Sprouty2 via down regulation of its target gene, 31/January/2015, 17.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for … Continue reading

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Vitamin-based therapy for Stroke: 1,25-dihydroxyvitamin D inhibits cerebral ischemia induced injury via down regulation of its target gene, 31/January/2015, 17.46

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Vitamin-based therapy for Stroke: 1,25-dihydroxyvitamin D inhibits cerebral ischemia induced injury via down regulation of its target gene, 31/January/2015, 17.46, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that 1,25-dihydroxyvitamin D, by … Continue reading

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Natural product-based therapy for pulmonary arterial hypertension: Ankaflavin inhibits the development of pulmonary arterial hypertension via up regulation of its target gene, 31/January/2014, 17.30

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy … Continue reading

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An Asprin a day will protect you from Myocardial Infarction: Asprin (acetyl salicylic acid) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 31/January/2015, 16.52

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature [I.F: >42] by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of … Continue reading

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Natural product-based therapy for life span extension: 6-shogaol, a natural compound isolated from Ginger, increases life span of mammals via down regulation of its target gene, 30/January/2014, 19.20

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for life span extension: 6-shogaol, a natural compound isolated from Ginger, increases life span of mammals via down regulation of its target gene, 30/January/2014, 19.20, Genome-2-Bio-Medicine … Continue reading

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Natural product-based therapy for pulmonary arterial hypertension: Monascin inhibits the development of pulmonary arterial hypertension via up regulation of its target gene, 30/January/2014, 19.05

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy … Continue reading

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Natural product-based therapy for pulmonary arterial hypertension: Agaricus blazei Murill, a medicinal mushroom, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene., 18.57

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy … Continue reading

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Vitamin-based therapy for Stroke: Vitamin-E inhibits cerebral ischemia induced injury via down regulation of its target gene, 30/January/2015, 18.45

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Vitamin-based therapy for Stroke: 1,25-dihydroxyvitamin D inhibits cerebral ischemia induced injury via down regulation of its target gene, 30/January/2015, 18.45, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that Vitamin-E, by suppressing … Continue reading

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Mechanistic insight into tumorigenesis: Cluster of Differentiation-24 (CD-24) suppresses the expression of tumor suppressor PTEN via down regulation of its target gene, 30/January/2015, 18.36

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorigenesis: Cluster of Differentiation-24 (CD-24) suppresses the expression of tumor suppressor PTEN via down regulation of its target gene, 30/January/2015, 18.36, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first … Continue reading

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Massage therapy for cancer patients: Massage attenuates inflammatory signalling-associated transformation and increases the expression of tumor suppressor PTEN via down regulation of its target gene, 30/January/2015, 18.33

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Massage therapy for cancer patients: Massage attenuates inflammatory signalling-associated transformation and increases the expression of tumor suppressor PTEN via down regulation of its target gene, 30/January/2015, 18.33, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, … Continue reading

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Natural product-based anti-cancer stem cell therapy: Agaricus blazei Murill, a medicinal mushroom, suppresses the expression of stem cell protein Oct-4 and increases the expression tumor suppressor genes via down regulation of its target gene, 30/January/20145, 18.26

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based anti-cancer stem cell therapy: Agaricus blazei Murill, a medicinal mushroom, suppresses the expression of stem cell protein Oct-4 and increases the expression tumor suppressor genes via down regulation … Continue reading

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Molecular therapy for Cancer: Tumor suppressor MiRNA miR-29c suppresses the expression of immortality gene telomerase via down regulation of its target gene, 30/January/2015, 18.14

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Molecular therapy for Cancer: Tumor suppressor MiRNA miR-29c suppresses the expression of immortality gene telomerase via down regulation of its target gene, 30/January/2015, 18.14, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests, for the … Continue reading

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Preserving the function of the guardian of the genome, p53: Luteolin inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 30/January/2015, 18.10

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Preserving the function of the guardian of the genome, p53:  Luteolin inhibits functional inactivation of p53 by somatic mutation and viral oncognes via up regulation of its target gene, 30/January/2015, 18.10, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Massage-based therapy for Stress-induced Memory loss: Massage promotes auditory fear memory formation by increassing the expression of Cortactin and Rac1, Genome-2-Bio-Medicine Discovery center (GBMD), 30/01/2015, 7.50 am

A study from the Department of Metabolism and Aging, The Scripps Research Institute, Florida, USA shows that “MicroRNA-182 regulates amygdala-dependent memory formation.” This study was published in the January 23, 2013 issue of J Neuroscience by Miller CA, Griggs EM and others from the Department of Metabolism and Aging, The Scripps Research … Continue reading

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