MiRNA-based Life-span extension therapy: Tumor suppressor p53 homologue p63 increases life span by suppressing mTOR pathway through up regulation of miRNA-130

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., MiRNA-based Life-span extension therapy: Tumor suppressor p53 homologue p63 increases life span by suppressing mTOR pathway through up regulation of miR-130, 27/January/2014, 22.43,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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 Significance:  This study suggests, for the first time, that p63, by increasing the expression of its target gene miRNA-130, it may suppress the expression of mTOR. Thereby, it may increase  the lifespan of an individual, as it has been shown earlier that decreasing the expression of mTOR increases overall lifespan. Together, this study suggests that pharmacological formulations encompassing “p63 or its activators or miRNA-130 or its activators” may function as longevity promoters.

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