MiRNA-based therapy for p53-mutated human tumors: MiRNA-760 promotes the tumor suppressor function of TAp73, premature senescence and inhibits the expression of cancer stem cell genes via down regulation of its target gene, 19/January/20145, 8.47 am

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, MiRNA-based therapy for p53-mutated human tumors: MiRNA-760 promotes the tumor suppressor function of TAp73, premature senescence, and inhibits the expression of cancer stem cell genes via down regulation of its target gene, 19/January/20145, 8.47 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that MiRNA-760, by decreasing the expression of its target gene, it may promote the tumor suppressor function of TAp73, premature senescence, and inhibit the expression of cancer stem cell genes. Thereby, it may promote tumor suppression. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured;  That is,  by activating its un-mutated homologous proteins, such as p73. Thus, pharmacological formulations encompassing “MiRNA-760 or its activators”  may be used to inhibit the progression of human tumors, including p53-mutated human tumors

Amount: $ 300

Undisclosed information: How MiRNA-760 increases the stability and activity of p73α

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