Natural product-based therapy for p53-mutated human tumors: Agaricus blazei Murill, a medicinal mushroom, promotes the tumor suppressor function of TAp73, increases senescence, and inhibits the expression of cancer stem cell genes via down regulation of its target gene, 29/January/20145, 22.59

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, Natural product-based therapy for p53-mutated human tumors: Agaricus blazei Murill, a medicinal mushroom, promotes the tumor suppressor function of TAp73, increases senescence, and inhibits the expression of cancer stem cell genes via down regulation of its target gene, 29/January/20145, 22.59, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that Agaricus blazei Murill, by decreasing the expression of its target gene, it may (1) promote the tumor suppressor function of TAp73; (2) increasee senescence, and; (3) inhibit the expression of cancer stem cell genes. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests a therapeutic strategy as to how mutant p53 expressing human cancers can be cured; that is,  by activating its un-mutated homologous proteins, such as p73, in cancer cells. Thus, pharmacological formulations encompassing “Agaricus blazei Murill or small molecule compounds isolated from Agaricus blazei Murill”  may be used to inhibit the progression of human tumors, including p53-mutated human tumors

Amount: $ 500

Undisclosed information: How Agaricus blazei Murill increases the stability and activity of p73α

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