Vitamin-based therapy for Acute Myeloid Leukeima (AML): ATRA suppresses the expression of 5-Lipoxygenase (5-LO) and inhibits cancer stem cell proliferation via up regulation of its target gene, 23/January/20145, 22.15

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Vitamin-based therapy for Acute Myeloid Leukeima (AML): ATRA suppresses the expression of 5-Lipoxygenase (5-LO) and inhibits cancer stem cell proliferation via up regulation of its target gene, 23/January/20145, 22.15, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that ATRA, by increasing the expression of its target geneit may suppress the expression of 5-Lipoxygenase (5-LO) and inhibit cancer stem cell proliferation. Thereby, it may prevent AML relapse after remission. Thus, pharmacological formulations encompassing ATRA or its analogues”  can be used to inhibit the progression and relapse of acute myeloid leukemia after remission.

Amount: $ 300

Undisclosed information: How ATRA suppresses the expression of 5-Lipoxygenase (5-LO)

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