MiRNA-based therapy for p53-mutated human tumors: MiRNA-19b suppresses the expression of p73α and promotes tumorigenesis via up regulation of its target gene, 3/February/2015, 12.24 am

Regenerative Stem cell therapy for Myocardial Infarction: P-ΔNp63α improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 3/February/2015, 12.19 am
February 2, 2015
Natural product-based antimetastatic therapy: Cirsilol suppresses the expression L1CAM via up regulation of its target gene, 3/February/20145, 12.30 am
February 2, 2015
Show all

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, MiRNA-based therapy for p53-mutated human tumors: MiRNA-19b suppresses the expression of p73α and promotes tumorigenesis via up regulation of its target gene, 3/February/2015, 12.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that MiRNA-19b, by decreasing the expression of its target gene, it may promote the stability and activity of tumor suppressor p53 homologue p73α. Thereby, it may promote tumor suppression. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured; that is, by activating its un-mutated homologous proteins, such as p73. Thus, pharmacological formulations encompassing “MiRNA-19b inhibitors”  can be used to inhibit the progression of human tumors, including p53-mutated human tumors

Amount: $ 300*

Undisclosed information: How MiRNA-19b suppresses the expression of p73α

Web: http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.