MiRNA-based therapy for cancer: MiRNA-181 increases wide-spread miRNA biogenesis via down regulation of its target gene, 14/February/2015, 12.15 am

Therapeutic insights into Arterial ageing: TGFβ inhibits Vascular Smooth Muscle Cells Senescence and the expression of senescence-associated pro-inflammatory proteins via up regulation of its target gene, 13/February/2015, 23.57
February 13, 2015
MiRNA-based Regenerative therapy for DM: p63-miR-130 pathway increases insulin-secreting cell mass and function via down regulation of its target genes, 14/February/2015, 11.23 am
February 14, 2015
Show all

Prof. Dr R I Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell InstituteBoston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”  

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based therapy for cancer:  MiRNA-181 increases wide-spread miRNA biogenesis via down regulation of its target gene.

Significance: It is known for years that miRNA biogenesis is decreased in a number of cancer cells. This study suggests, for the first time, that MiRNA-181, by suppressing the expression of its target gene, it may increase wide-spread miRNA biogenesis. Thereby, it may inhibit cancer progression.  Thus, pharmacological formulations encompassing “MiRNA-181 or its activators” may be used to inhibit cancer progression

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, MiRNA-based therapy for cancer:  MiRNA-181 increases wide-spread miRNA biogenesis via down regulation of its target gene, 14/February/2015, 12.15 am

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Amount: $500*

Undisclosed information: How miR-181 increases wide-spread miRNA biogenesis

Comments are closed.