MiRNA-based therapy for p53-mutated human tumors: MiRNA-342-3p increases the expression of p73α and inhibits tumorigenesis via down regulation of its target gene, 3/February/2015, 22.51

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, MiRNA-based therapy for p53-mutated human tumors: MiRNA-342-3p increases the expression of p73α and inhibits tumorigenesis via down regulation of its target gene, 3/February/2015, 22.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that MiRNA-342-3p, by decreasing the expression of its target gene, it may promote the stability and activity of tumor suppressor p53 homologue p73α. Thereby, it may promote tumor suppression. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured; that is, by activating its un-mutated homologous proteins, such as p73. Thus, pharmacological formulations encompassing “MiRNA-342-3p activators”  can be used to inhibit the progression of human tumors, including p53-mutated human tumors

Amount: $ 500*

Undisclosed information: How MiRNA-342-3p increases the expression of p73α

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* Research cooperation

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