Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, Natural product-based therapy for cancer: Tumor suppressor p53 homologues p73 and p63 suppress the expression of oncoprotein Mcl-1 and increase the expression of proapoptotic protein BIM via down regulation of their target genes, 14/February/2015, 23.17, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study suggests that p63 and p73, by increasing the expression of their target genes, they may decrease the expression of Mcl-1 and increase the expression of proapoptotic protein BIM. Thereby, they may inhibit the progression of drug resistant cancer cells. Thus, pharmacological formulations encompassing “TA-p63/p73 activator” can be used to inhibit the progression of human tumors, including Melanoma.
Amount: $ 300
Undisclosed information: How p63 and p73 suppress the expression of Mcl-1 and increase the expression of BIM
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