Natural product-based therapy for pulmonary arterial hypertension: I3C, a natural product of Brassica vegetables, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene, 4/February/2015, 22.06

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: I3C, a natural product of Brassica vegetables, attenuates pulmonary hypertension  inhibits the development of pulmonary arterial hypertension via down […]

Molecular therapy for Stroke: I3C inhibits cerebral ischemia induced injury via up regulation of its target gene, 4/February/2015, 22.00

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Molecular therapy for Stroke:  I3C, a natural product of Brassica vegetables, inhibits cerebral ischemia induced injury via up regulation of its target gene, 4/February/2015, 22.00, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that  I3C, a natural product of Brassica vegetables, by suppressing the expression of its target […]

Natural product-based therapy for Human Cancer: Cirsilol suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 4/February/2015, 21.45

The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of […]

Natural product-based therapy for pulmonary arterial hypertension: Chlorogenic acid inhibits the development of pulmonary arterial hypertension via up regulation of its target gene, 4/February/2015, 9.44 am

A study from the University of California, La Jolla, CA, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of Nature Medicine by Prof. Thistlethwaite PA, Li X and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary arterial hypertension: Chlorogenic acid inhibits the development of pulmonary arterial hypertension via up regulation of its target gene. Together, pharmacological formulations encompassing “Chlorogenic acid or […]

MiRNA based cancer therapy: MiRNA-29 inhibits cancer development by decreasing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 4/February/2014, 9.15 am

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. On the foundation of this interesting […]

Molecular therapy for Stroke: CDX2 inhibits cerebral ischemia induced injury via down regulation of its target gene, 4/February/2015, 12.03 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Molecular therapy for Stroke:  CDX2 inhibits cerebral ischemia induced injury via down regulation of its target gene, 4/February/2015, 12.03 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that CDX2, by suppressing the expression of its target gene, it may inhibit cerebral ischemia induced injury. Thus, pharmacological formulations encompassing “CDX2 […]