March

March 31, 2015

Natural product-based therapy for hypertensive cardiovascular diseases: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses Ang II-induced hypertensive cardiac remodelling via down regulation of its target gene., 31/March/2015, 23.24

A recent study from the Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China shows that “Smad7 inhibits angiotensin II-induced hypertensive […]
March 31, 2015

Natural product-based therapy for p53-deficient tumors: I3C, a natural compound found in Broccoli & Brussels, suppresses & increases the expression of DNp63α & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 31/3/2015, 22.46

A recent study from the Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] […]
March 31, 2015

Natural product-based therapy for regional enteritis disease: Oleic acid, the main component of Neem oil, increases the expression of immunosuppressive cytokine TGF-β1 and inhibits the progression of regional enteritis disease via up regulation of its target gene, 31/March/2015, 22.25

A recent study from the Department of Systems Medicine, University of Tor Vergata, Italy shows that Mongersen, an oral SMAD7 antisense oligonucleotide, inhibits regional enteritis disease. This study was published in […]
March 31, 2015

Therapeutic insights into “awakening the sleeping angel” in p53-mutated human tumors: MiRNA-214 increases the expression of tumor suppressor p53 homologue TAp73 and inhibits tumorigenesis via down regulation of its target gene, 31/3/2015, 21.36

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Significance: Cancer suppressor p53 is mutated in more than 50% of different human cancers.  This study suggests, for the first time, a therapeutic […]