Monthly Archives: March 2015

Natural product-based therapy for hypertensive cardiovascular diseases: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses Ang II-induced hypertensive cardiac remodelling via down regulation of its target gene., 31/March/2015, 23.24

A recent study from the Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China shows that “Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling.” This study was published in the 1 September’13 issue of of the Journal “Cardiovascular … Continue reading

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Natural product-based therapy for p53-deficient tumors: I3C, a natural compound found in Broccoli & Brussels, suppresses & increases the expression of DNp63α & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 31/3/2015, 22.46

A recent study from the Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 … Continue reading

Comments Off on Natural product-based therapy for p53-deficient tumors: I3C, a natural compound found in Broccoli & Brussels, suppresses & increases the expression of DNp63α & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 31/3/2015, 22.46

Natural product-based therapy for regional enteritis disease: Oleic acid, the main component of Neem oil, increases the expression of immunosuppressive cytokine TGF-β1 and inhibits the progression of regional enteritis disease via up regulation of its target gene, 31/March/2015, 22.25

A recent study from the Department of Systems Medicine, University of Tor Vergata, Italy shows that Mongersen, an oral SMAD7 antisense oligonucleotide, inhibits regional enteritis disease. This study was published in the 19 March 2015 issue of of the Journal “N. Engl. J. Med.” [I.F: 54.42]  by Prof Pallone … Continue reading

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Therapeutic insights into “awakening the sleeping angel” in p53-mutated human tumors: MiRNA-214 increases the expression of tumor suppressor p53 homologue TAp73 and inhibits tumorigenesis via down regulation of its target gene, 31/3/2015, 21.36

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Significance: Cancer suppressor p53 is mutated in more than 50% of different human cancers.  This study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancers can be cured by activating its … Continue reading

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Small molecule-based therapy for metastatic tumors: Nutlin inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 31/March/2015, 21.19

A recent study from the Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland shows that “GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.” This study was published … Continue reading

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Natural product-based Lifespan extension therapy: Icariin, a flavanoid and PDE-5 inhibitor, may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 31/March/2014, 10.18 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Icariin, a flavanoid and PDE-5 inhibitor, may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 31/March/2014, 10.18 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org … Continue reading

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Natural product-based therapy for Myocardial Infarction: Pear extract improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 31/March/2015, 9.23 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of of the Journal “Nature” [I.F: 42]  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Comments Off on Natural product-based therapy for Myocardial Infarction: Pear extract improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 31/March/2015, 9.23 am

Interleukin-based therapy for prevention of Stress-induced heart failure: Interleukin-6 (IL-6) protects against stress-induced heart failure via up regulation of SNX13, 31/March/2015, 8.17 am

A recent study from the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China shows that “SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain.” This study … Continue reading

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GOD can stall cancer spread: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 31/March/2015, 8.06 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., GOD can stall cancer spread: Celastrol,  an antioxidant & anti-inflammatory drug from herb Thunder of God vine,  inhibits invasion and metastasis by altering protein trafficking via up regulation of … Continue reading

Comments Off on GOD can stall cancer spread: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 31/March/2015, 8.06 am

Regenerative therapy for DM: Ars2 (arsenite-resistance protein 2/Serrate RNA effector molecule homolog) promotes an insulin-sensitized state via up regulation of reprogramming protein Lin28, 31/March/2015, 7.39 am

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” … Continue reading

Comments Off on Regenerative therapy for DM: Ars2 (arsenite-resistance protein 2/Serrate RNA effector molecule homolog) promotes an insulin-sensitized state via up regulation of reprogramming protein Lin28, 31/March/2015, 7.39 am

MiRNA-based therapy for Myocardial ischemia: MiRNA-214 inhibits cardiac ischemia via up regulation of Aldehyde dehydrogenase 2 (ALDH2), 30/March/2015, 22.39

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based therapy for Myocardial ischemia: MiRNA-214 inhibits cardiac ischemia via up regulation of Aldehyde dehydrogenase 2 (ALDH2), 30/March/2015, 22.38, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: The study presented here suggests that MiRNA-214, by decreasing the expression … Continue reading

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Natural product-based Anti-metastasis therapy: EF24 (curcumin analog) inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 30/March/2015, 21.56

A recent study from the From the Centre for Cancer Biology, an Alliance between SA Pathology and University of South Australia, Adelaide, South Australia 5000, Australia. Discipline of Biochemistry, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia … Continue reading

Comments Off on Natural product-based Anti-metastasis therapy: EF24 (curcumin analog) inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 30/March/2015, 21.56

Anti-metastatic therapy: MiRNA-107 suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 29/March/2015, 21.33

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastatic therapy: MiRNA-107 suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 29/March/2015, 21.33, Genome-2-Bio-Medicine Discovery … Continue reading

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Natural product-based therapy for Myocardial Infarction: Thermostable extract of fenugreek seeds (TEFS) improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 30/March/2015, 15.05

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of of the Journal “Nature” [I.F: 42]  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Comments Off on Natural product-based therapy for Myocardial Infarction: Thermostable extract of fenugreek seeds (TEFS) improves ageing- and stress-associated decline in cardiac function via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 30/March/2015, 15.05

Natural product-based Lifespan extension therapy: Alpha-lipoic acid may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 30/March/2014, 14.54

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Alpha-lipoic acid may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 30/March/2014, 14.54, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Shear therapy for Lifespan extension: Shear force inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) via up regulation of its target gene, 30/January/2015, 10.24 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

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Small molecule-based Life-span extension therapy: Cardiotrophin-1 (CT-1) extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 30/March/2014, 9.36 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Life-span extension therapy: Cardiotrophin-1 (CT-1) extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 30/March/2014, 9.35 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

Comments Off on Small molecule-based Life-span extension therapy: Cardiotrophin-1 (CT-1) extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 30/March/2014, 9.36 am

Regenerative therapy for DM: Cardiotrophin-1 (CT-1) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 30/March/2015, 8.45 am

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA. shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” … Continue reading

Comments Off on Regenerative therapy for DM: Cardiotrophin-1 (CT-1) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 30/March/2015, 8.45 am

Immune enhancement therapy: Inhibitor of differentiation-4 (Id4) increases SOX2 expression and promotes innate immunity against bacterial infection, 30/March/2015, 8.29 am

A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 … Continue reading

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Natural product-based therapy for metastatic tumors: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 30/March/2015, 6.49 am

A recent study from the Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland shows that “GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.” This study was published … Continue reading

Comments Off on Natural product-based therapy for metastatic tumors: Agaricus blazei Murill (AbM), a medicinal mushroom, inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 30/March/2015, 6.49 am