Natural product-based therapy for p53-deficient tumors: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses & increases the expression of DNp63α & IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 18/March/2015, 10.07 am

A recent study from the Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Graduate School of Biomedical Sciences, The University of […]

Androgen therapy for Metastatic tumors: Testosterone decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 18/March/2015, 8.48 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Androgen therapy for Metastatic tumors: Testosterone decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 18/March/2015, 8.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  It has recently been shown that blocking PD-1 with antibodies one could […]

Brown rice as an anti-metastatic agent: Germinated brown rice (GBR) suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 18/March/2015, 8.40 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Brown rice as an anti-metastatic agent: Germinated brown rice (GBR) suppresses the expression of actin-regulatory proteins FHOD1 and PPM1F and inhibits migration and invasion of metastatic cancer cells via up regulation of its target gene, 18/March/2015, 8.40 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: The study presented here suggests that […]

Molecular therapy for p53-mutated Human Cancers: Roquin [RING finger and CCCH-type zinc finger domain-containing protein 1] increases the expression of tumor suppresor TA-p63 via down regulation of its target gene, 18/March/2015, 8.14 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: Cancer suppressor p53 is mutated in more than 50% of different human cancers.  This study suggests a therapeutic strategy as to how mutant p53 expressing human cancers can be cured by activating its “unmutated homologous proteins”, such as TAp63.  Roquin, by down regulation of its target gene, it may increase […]