MiRNA-based therapy for Fibrosis: BMP4 suppresses TGFβ-dependent extracellular matrix accumulation and fibrosis via up regulation of its target gene, 21/March/2015, 17.09

A recent study from the Center for Cardiovascular and Pulmonary Research and Heart Center, Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Columbus shows that “MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells.” This study was published in the 2 January 2015 issue of the  Journal “Circulation Research” by Prof. Lilly B, Zhao N and others. On the […]

MiRNA-based therapy for hypoxia/inflammation-associated brain damage: TGFβ decreases infarct size, edema formation, neutrophil infiltration and promotes neuronal survival via down regulation of TIM-3, 21/March/2015, 16.37

A recent study from the Cancer Immunology Branch, Department of System Cancer Science, National Cancer Center, 111 jungbalsan-ro, Kyunggi 410-769, Republic of Korea; and Department of Physiology, Development and Neuroscience, University of Cambridge, UK shows that “The HIF-1/glial ​TIM-3 axis controls inflammation-associated brain damage under hypoxia.” This study was published in the 20 March 2015 issue of the online Journal “Nature Communications” by Drs. Park […]

MiRNA-based therapy for T2DM: MiRNA-518c inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 21/March/2015, 6.57 am

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >42] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. […]

Natural product-based Immune enhancement therapy: Withaferin A, a natural compound derived from W. Somnifera, increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 21/March/2015, 06.42 am

A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [I.F: 24.973] by Drs. Zusen Fan, Xia and others. On the […]