MiRNA-based antimetastasis therapy: MiRNA-181 inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 26/March/2015, 10.29 am

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A recent study from the Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland shows that GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.” This study was published in the 29 July  2014 issue of the Journal “Cell Metabolism” (the no.1 journal in Metabolism; and I.F: 16.747) by Prof. Etienne Meylan, Masin M and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  MiRNA-based antimetastasis therapy: MiRNA-181 inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3.

Significance:  The study presented here suggests, for the first time, that MiRNA-181, by suppressing the expression of its target gene, it may decrease the expression of GLUT3. Thereby, it may inhibit glycolysis. Thus, pharmacological formulations encompassing ” MiRNA-181 activators” may be used to stall the progression of invasive human tumors.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, MiRNA-based antimetastasis therapy: MiRNA-181 inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 26/March/2015, 10.29 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How  MiRNA-181 suppresses the expression of GLUT3

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