MiRNA-based Immune enhancement therapy: MiRNA-375 increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 23/March/2015, 15.16

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A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [I.F: 24.973] by Drs. Zusen Fan, Xia and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Immune enhancement therapy: MiRNA-375  increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene. This study suggests, for the first time, MiRNA-638, by increasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing MiRNA-375  activators” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  MiRNA-based Immune enhancement therapy: MiRNA-375 increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 23/March/2015,  15.15,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How MiRNA-375 (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance.

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