MiRNA-based therapy for pulmonary hypertension: MiRNA-221 suppresses pulmonary hypertension via down regulation of its target gene, 11/March/2015, 21.57

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A recent study from the from the Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, United States of America shows that “High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4. This study was published in the 8 Feb’13  issue of the Journal “Molecular Medicine”  by Drs. Bauer PMBauer EM and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based therapy for pulmonary hypertension: MiRNA-221 suppresses pulmonary hypertension via down regulation of its target gene. This study suggests, for the first time, that MiRNA-221, by decreasing the expression of its target gene, may: (1) decrease Right ventricular systolic pressure, and (2) inhibit thickening of the pulmonary artery wall. Together, pharmacological formulations encompassing “MiRNA-221 or its activators may be used to treat patients suffering from pulmonary hypertension.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  MiRNA-based therapy for pulmonary hypertension: MiRNA-221 suppresses pulmonary hypertension via down regulation of its target gene, 11/March/2015,  21.57,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How MiRNA-221 stifles pulmonary hypertension

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