Natural product-based Immune enhancement therapy: Withaferin A, a natural compound derived from W. Somnifera, increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 21/March/2015, 06.42 am

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A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [I.F: 24.973] by Drs. Zusen Fan, Xia and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based Immune enhancement therapy: Withaferin A, a natural compound derived from W. Somnifera,  increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene. This study suggests, for the first time, Withaferin A, by increasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing Withaferin A  or its analogues” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  Natural product-based Immune enhancement therapy: Withaferin A increases SOX2 expression and promotes innate immunity against bacterial infection via up regulation of its target gene, 21/March/2015,  06.42 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How Withaferin A (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance.

Amount: $500*

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