Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product-based Life-span extension therapy: Epigallocatechin gallate, the main component of Green tea, inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 20/March/2014, 13.54, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that Epigallocatechin gallate, by increasing the expression of its target gene, it may suppress the expression of ADCY5/AC5. Thereby, it may extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Epigallocatechin gallate or its analogues” may be used to extend the life-span of an an individual.
Undisclosed information: How Epigallocatechin gallate suppresses the expression of adenylate cyclase 5 (ADCY5)