Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Life-span extension therapy: LIF inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 23/March/2014, 15.05, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that LIF, by increasing he expression of its target gene, it may suppress the expression of ADCY5/AC5 expression. Thus, pharmacological formulations encompassing “LIF activators“ may be used to extend the life-span of an an individual.
Undisclosed information: How LIF suppresses the expression of adenylate cyclase 5 (ADCY5)