Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Natural product-based Life-span extension therapy: Mef2 inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 17/March/2014, 15.20, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that Mef2 protein, by increasing he expression of its target gene, it may suppress the expression of ADCY5/AC5 expression. Thereby, it may extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Mef2 activators“ may be used to extend the life-span of an an individual.
Undisclosed information: How Mef2 suppresses the expression of adenylate cyclase 5 (ADCY5)