Natural product-based Life-span extension therapy: Natural product Cucurbitacin I (JSI-124) inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 19/March/2014, 22.02

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product-based Life-span extension therapy: Natural product Cucurbitacin I (JSI-124) inhibits senescence and  extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 19/March/2014, 22.02, Genome-2-Bio-Medicine Discovery center (GBMD),


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Significance: This study suggests, for the first time, that Cucurbitacin I may extend the lifespan of an individual by suppressing ADCY5/AC5 expression. Thus, pharmacological formulations encompassing Cucurbitacin I or its analogues” may be used to extend the life-span of an an individual.

Undisclosed information: How Cucurbitacin I suppresses the expression of  adenylate cyclase 5 (ADCY5)

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