Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Alpha-lipoic acid may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 30/March/2014, 14.54, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that Alpha-lipoic acid, by increasing the expression of its target gene, it may suppress the expression of AT1R. Thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Alpha-lipoic acid or its analogues” may be used to extend the life-span of an individual.
Undisclosed information: How Alpha-lipoic acid suppresses the expression of angiotensin II type I receptor (AT1R)