Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural-product based therapy for Acute Renal injury: Icariin inhibits renal inflammation by inhibiting inflammasome activation pathway, 16/March/2014, 06.31 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that Icariin, by increasing the expression of its target gene, it may inhibit the inflammasome activation pathway. Thereby, it may decrease renal inflammation. Thus, pharmacological formulations encompassing “Icariin or its analogues” may be used to treat renal inflammatory disease.
Undisclosed information: How Icariin inhibits the inflammasome activation pathway