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A recent study from the Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland shows that GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer.” This study was published in the 29 July  2014 issue of the Journal “Cell Metabolism” (the no.1 journal in Metabolism; and I.F: 16.747) by Prof. Etienne Meylan, Masin M and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-based therapy for metastatic human tumors: Glabridin (GLA), found in the roots of liquorice, inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3.

Significance:  The study presented here suggests, for the first time, that Glabridin (GLA), by increasing the expression of its target gene, it may decrease the expression of GLUT3. Thereby, it may inhibit glycolysis. Thus, pharmacological formulations encompassing “Glabridin or its analogues”  can be used to inhibit the progression of invasive human tumors.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product-based therapy for metastatic human tumors: Glabridin (GLA) inhibits epithelial-mesenchymal transition and cancer cell proliferation via down regulation of GLUT3, 18/March/2015, 13.17, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Glabridin (GLA) suppresses the expression of GLUT3

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