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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product-based therapy for Metastatic tumors: Triptolide, a natural compound found in the herb Thunder of God Vine, decreases the expression of PD-1, a suppressor of activation of T-cells, via down regulation of its target gene, 5/March/2015, 11.11 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that Triptolide, by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing “Triptolide or its analogues  may be used to inhibit the progression of tumors.

Amount: $ 500*

Undisclosed information: How  Triptolide decreases the expression of PD-1

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