Natural product based therapy for protecting myocardium from oxidative stress: Withaferin A, a natural compound derived from Withania somnifera, suppresses the expression of mitochondrial calcium uniporter (MCU) and protects cardiomyocytes against oxidative damage via up regulation of its target gene, 16/March/2015, 21.51

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product based therapy for protecting myocardium from oxidative stress: Withaferin A, a natural compound derived from Withania somnifera, suppresses the expression of mitochondrial calcium uniporter (MCU) and protects cardiomyocytes against oxidative damage via up regulation of its target gene, 16/March/2015, 21.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that Withaferin A, by increasing the expression of its target gene, it may suppress the expression of mitochondrial calcium uniporter (MCU)Thereby, it may  protect cardiomyocytes against oxidative damage.  Thus, pharmacological formulations encompassing “Withaferin A or its analogues”  can be used to stressed myocardium.

Undisclosed information: How Withaferin A  decreases mitochondrial calcium uniporter (MCU) 

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