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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural-product based therapy for Sepsis:  Piceatannol,  a natural compound found in passion fruit (Passiflora edulis),  inhibits lung inflammation by inhibiting inflammasome activation pathway, 20/March/2014, 09.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: Uncontrolled/excessive inflammation is the principle cause of  tissue damage during sepsis. This study suggests, for the first time, that Piceatannol, by increasing the expression of its target gene, it may inhibit the inflammasome activation pathway. Thereby, it may decrease acute lung inflammation during sepsis. Thus, pharmacological formulations encompassing “Piceatannol or its analogues” may be used to treat acute lung inflammation during Sepsis.

Undisclosed information: How Piceatannol inhibits the inflammasome activation pathway during Sepsis

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