March

March 18, 2015

Molecular therapy for p53-mutated Human Cancers: Roquin [RING finger and CCCH-type zinc finger domain-containing protein 1] increases the expression of tumor suppresor TA-p63 via down regulation of its target gene, 18/March/2015, 8.14 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: Cancer suppressor p53 is mutated in more than 50% of different human cancers.  This study suggests a therapeutic strategy […]
March 17, 2015

Small molecule-based therapy for Human Cancer: Nutlin suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 17/March/2015, 22.38

The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that “The TEL […]
March 17, 2015

Turning on senescence turns off cancer progression: Curcumin, the major component of turmeric, induces telomere dysfunction and senescence via down regulation of Telomeric repeat binding factor 2 (TRF2), 17/March/2015, 15.40

A recent study from the Key Laboratory of Gene Engineering of the Ministry of Education, Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences […]
March 17, 2015

Vitamin-based therapy for pulmonary hypertension: Cholecalciferol stifles pulmonary hypertension via down regulation of its target gene, 17/March/2015, 15.34

A recent study from the From the Department of Surgery, University of Pittsburgh Cancer Institute, Division of Pediatric Surgery, Children’s Hospital Pittsburgh, Department of Pharmacology and […]