Regenerative therapy for DM: RREB (Ras-responsive element-binding protein 1) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 29/March/2015, 23.00

Natural product-based Anti-metastasis therapy: I3C, a natural compound found in Broccoli & Brussels, inhibits invasion and metastasis by altering protein trafficking via up regulation of tumor suppressor PTPN14 (Pez), 29/March/2015, 22.47
March 29, 2015
Molecular therapy for Myocardial ischemia: C/EBPβ inhibits cardiac ischemia via up regulation of Aldehyde dehydrogenase 2 (ALDH2), 28/March/2015, 23.03
March 29, 2015
Show all

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA. shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [33.116]  by Prof Daley GQ, Zhu H, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative therapy for DM: RREB (Ras-responsive element-binding protein 1) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28. 

Significance: Prof. Daley GQ‘s laboratory has shown that loss of Lin28 promotes insulin resistance and glucose intolerance. This study suggests, for the first time, that RREB, by increasing the expression of its target gene, it may increase the expression of RNA-binding protein Lin-28 and thereby promote insulin sensitivity.  Thus, pharmacological formulations encompassing “RREB activators” may be used to treat DM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed information: How RREB  increases the expression of Lin28

To citeBoominathan, Regenerative therapy for DM: RREB (Ras-responsive element-binding protein 1) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 29/March/2015, 23.00,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.