Monthly Archives: April 2015

The Exercise-Mimicking pills may inhibit Insulin resistance and decrease adiposity: BMB4 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, improves muscle insulin sensivitity and decreases adiposity via up regulation of its target gene, 1/May/2015, 12.19 am

Significance: This study suggests, for the first time, that BMP4, by increasing the expression of its target gene, it may: (1) decrease the expression of gluconeogenesis genes, such as PEPCK and G6Pase; (2) reduce hepatic glucose production; (3) improve muscle insulin sensitivity; … Continue reading

Comments Off on The Exercise-Mimicking pills may inhibit Insulin resistance and decrease adiposity: BMB4 decreases gluconeogenesis genes, such as PEPCK and G6Pase, reduces hepatic glucose production, improves muscle insulin sensivitity and decreases adiposity via up regulation of its target gene, 1/May/2015, 12.19 am

Turning on senescence turns off cancer progression: HIF-1α inhibits telomere dysfunction and senescence via up regulation of Telomeric repeat binding factor 2 (TRF2), 30/April/2015, 23.57

A recent study from the Key Laboratory of Gene Engineering of the Ministry of Education, Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China shows that “Mir-23a induces telomere … Continue reading

Comments Off on Turning on senescence turns off cancer progression: HIF-1α inhibits telomere dysfunction and senescence via up regulation of Telomeric repeat binding factor 2 (TRF2), 30/April/2015, 23.57

Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: SNAI, an activator of epithelial-mesenchymal transition, increases the expression of ERBB2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 30/April/2014, 23.37

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature cell biology” (the number … Continue reading

Comments Off on Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: SNAI, an activator of epithelial-mesenchymal transition, increases the expression of ERBB2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 30/April/2014, 23.37

Molecular therapy for wound healing: Succinate, one of the component in the TCA cycle, enhances skin wound healing and attenuates pathological scarring via down regulation of its target gene, 30/April/2014, 23.23

A recent study from the Department of Pathology, School of Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan shows that “Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.” This study was published in the 8 July  2014 issue of Am … Continue reading

Comments Off on Molecular therapy for wound healing: Succinate, one of the component in the TCA cycle, enhances skin wound healing and attenuates pathological scarring via down regulation of its target gene, 30/April/2014, 23.23

MiRNA-based Immune augmentation therapy: MiRNA-96 promotes NK cell maturation and function via up regulation of its target gene, 30/April/2014, 19.23

A recent study from the Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; The James Cancer Hospital, The Ohio State University, Columbus, OH, USA shows … Continue reading

Comments Off on MiRNA-based Immune augmentation therapy: MiRNA-96 promotes NK cell maturation and function via up regulation of its target gene, 30/April/2014, 19.23

Interleukin-based therapy for DM: Interleukin-17B (IL-17B) inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 30/April/2015, 18.27

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >42] by Prof. Puigserver and others from the Department … Continue reading

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Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 30/April/2015, 18.19

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 30/April/2015, 18.19, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: The … Continue reading

Posted in Ideas | Comments Off on Anti-metastasis therapy: MiRNA-134 increases the expression of TPM1 (tropomyosin) and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 30/April/2015, 18.19

Natural product-based therapy for pulmonary arterial hypertension: Piperidine alkaloids, isolated from P. retrofractum Vahl. (PRPAs), inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 30/April/2015, 09.39 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

Comments Off on Natural product-based therapy for pulmonary arterial hypertension: Piperidine alkaloids, isolated from P. retrofractum Vahl. (PRPAs), inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 30/April/2015, 09.39 am

Natural product-based Regenerative therapy for Diabetes mellitus: Pear extract increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 30/April/2015, 9.33 am

A study from the Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA and Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA  shows that “A … Continue reading

Comments Off on Natural product-based Regenerative therapy for Diabetes mellitus: Pear extract increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 30/April/2015, 9.33 am

Regenerating the lost pancreatic β cells in Diabetic patients: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 30/April/2015, 09.25 am

A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, … Continue reading

Comments Off on Regenerating the lost pancreatic β cells in Diabetic patients: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 30/April/2015, 09.25 am

Mechanistic insight into tumorigenesis: Apolipoprotein E (apoE) increases the expression of immortality gene telomerase via up regulation of its target gene, 29/April/2015, 21.49

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into tumorigenesis: Apolipoprotein E (apoE) increases the expression of immortality gene telomerase via up regulation of its target gene, 29/April/2015, 21.49, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that … Continue reading

Comments Off on Mechanistic insight into tumorigenesis: Apolipoprotein E (apoE) increases the expression of immortality gene telomerase via up regulation of its target gene, 29/April/2015, 21.49

Natural product-based therapy for pulmonary arterial hypertension: B. pandurata extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 29/April/2015, 21.45

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

Comments Off on Natural product-based therapy for pulmonary arterial hypertension: B. pandurata extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 29/April/2015, 21.45

MiRNA-based Anti-ageing therapy: Interleukin-17B increases the expression of immortality gene telomerase via down regulation of its target genes, 29/April/2015, 15.12

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Anti-ageing therapy: Interleukin-17B increases the expression of immortality gene telomerase via down regulation of its target genes, 29/April/2015, 15.12, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been shown earlier that transgenic expression of telomerase … Continue reading

Comments Off on MiRNA-based Anti-ageing therapy: Interleukin-17B increases the expression of immortality gene telomerase via down regulation of its target genes, 29/April/2015, 15.12

Molecular therapy for DM: Upregulator of cell proliferation inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 29/April/2015, 13.35

A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >42] by Prof. Puigserver and others from the Department … Continue reading

Comments Off on Molecular therapy for DM: Upregulator of cell proliferation inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, 29/April/2015, 13.35

Regenerative Stem cell therapy for Myocardial Infarction: ZEB1, an inducer of Epithelial to Mesenchymal transition, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/April/2015, 10.36 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative … Continue reading

Comments Off on Regenerative Stem cell therapy for Myocardial Infarction: ZEB1, an inducer of Epithelial to Mesenchymal transition, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/April/2015, 10.36 am

A known drug of an unknown Immune augmentation function: Acarbose, a widely used in the treatment of T2DM, promotes NK cell maturation and function via up regulation of its target gene, 29/April/2014, 9.35 am

A recent study from the Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; The James Cancer Hospital, The Ohio State University, Columbus, OH, USA shows … Continue reading

Comments Off on A known drug of an unknown Immune augmentation function: Acarbose, a widely used in the treatment of T2DM, promotes NK cell maturation and function via up regulation of its target gene, 29/April/2014, 9.35 am

Shear therapy accelarates wound healing and prevents scarring: Shear therapy enhances skin wound healing and attenuates pathological scarring via down regulation of its target gene, 29/April/2014, 8.01 am

A recent study from the Department of Pathology, School of Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan shows that “Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.” This study was published in the 8 July  2014 issue of Am … Continue reading

Comments Off on Shear therapy accelarates wound healing and prevents scarring: Shear therapy enhances skin wound healing and attenuates pathological scarring via down regulation of its target gene, 29/April/2014, 8.01 am

Natural product-based Regenerative therapy for T2D: Exendin-4 promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 29/April/2015, 07.47

A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, … Continue reading

Comments Off on Natural product-based Regenerative therapy for T2D: Exendin-4 promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 29/April/2015, 07.47

Lifespan extension therapy: p73 and p63 promote cellular fitness and life span via up regulation of their target gene, 29/April/2014, 7.41 am

A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.“ This study was published in the 15 October  2005 issue of … Continue reading

Comments Off on Lifespan extension therapy: p73 and p63 promote cellular fitness and life span via up regulation of their target gene, 29/April/2014, 7.41 am

MiRNA-based anti-metastasis therapy: MiRNA-139 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 29/April/2015, 7.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based anti-metastasis therapy: MiRNA-139 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 29/April/2015, 7.33 am, Genome-2-Bio-Medicine Discovery … Continue reading

Comments Off on MiRNA-based anti-metastasis therapy: MiRNA-139 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 29/April/2015, 7.33 am