A study from the Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA; and College of Physicians and Surgeons, Columbia University, New York, USA shows that “A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.” This study was published in the 9 Feb 2015 issue of the Journal “Cancer cell” (the no.1 journal in cancer biology with an impact factor of 23.893) by Prof Domingo-Domenech J, Vidal SJ, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Exposing to optimal sun light may extinguish metastatic Prostate cancer spread: Calcitriol (1α, 25-dihydroxyvitamin D3) suppresses GATA2-IGF2 axis and halts the progression of prostate cancer.
Significance: Given that prostate cancer is/had: (1) one of the most frequently diagnosed cancer in males; (2) the sixth leading cause of cancer death in males worldwide; and (3) caused 256,000 deaths in 2010, there is an urgent need to find an effective therapy for prostate cancer. This study suggests, for the first time, that Calcitriol (1α, 25-dihydroxyvitamin D3), by increasing the expression of its target gene, it may decrease the expression of its target gene IGF2. Thereby, it may inhibit the GATA2-IGF2 axis in aggressive prostate cancer. Thus, pharmacological formulations encompassing “Calcitriol or its analogues” may be used to inhibit the progression of prostate cancer. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D, one may expose to the optimal level of sunlight to stall metastatic cancer progression.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Exposing to the optimal sunlight may extinguish metastatic Prostate cancer spread: Calcitriol (1α, 25-dihydroxyvitamin D3) suppresses GATA2-IGF2 axis and halts the progression of prostate cancer, 11/April/2015, 11.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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