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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Significance: Sildenafil is used in the treatment of erectile dysfunction and pulmonary arterial hypertension. Sildenafil, by increasing the expression of its target gene, it may increase the negative regulator of stress responsive protein p53, MDM2. Thereby, it may (1) decrease p53 levels; and (2) turn off stress reactions. Thus, pharmacological formulations encompassing “Sildenafil or its analogues” may be used to treat treat stressed individuals.

Undisclosed information: How Sildenafil  increases the expression of MDM2

CitationBoominathan, L., Anti-stress therapy: Sildenafil, a phosphodiestrase-5 inhibitor,  increases the expression of MDM2, a negative regulator of stress responsive protein p53, via up regulation of its target gene, 15/April/2015, 9.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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