Regenerating the lost pancreatic β-cells in DM patients: mTORC2 increases insulin-secreting cell mass and function via up regulation of its target genes, 21/March/2015, 15.12

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A recent study from the “Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA” shows that mTOR complex 2 controls glycolytic metabolism … through FoxO acetylation and upregulation of c-Myc.” This study was published in the 17 October  13′ issue of the Journal “Cell Metabolism” by Prof Mischel PS, Masui K and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerating the lost pancreatic β-cells in DM patients: mTORC2 increases insulin-secreting cell mass and function via up regulation of its target genes, 21/March/2015, 15.12, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that mTORC2, by decreasing the expression of its target gene, it may increase insulin-secreting cell mass and functionThereby, it may increase insulin sensitivity of cellular tissues.  Thus, pharmacological formulations encompassing mTORC2 activators”  can be used to treat DM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Regenerating the lost pancreatic β-cells in DM patients: mTORC2 increases insulin-secreting cell mass and function via up regulation of its target genes, 21/March/2015, 15.09, 21/April/2014,  15.12,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How mTORC2 increases insulin-secreting cell mass and function

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