A recent study from the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology”[I.F: 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Immune enhancement therapy: AICAR, an analog of AMP, increases SOX2 expression and promotes innate immunity against bacterial infection. This study suggests, for the first time, that AICAR, by decreasing the expression of its target gene, it may increase/promote: (1) the expression of Sox2; (2) the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) innate immunity against bacterial infection. Together, pharmacological formulations encompassing “AICAR or its analogues” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Immune enhancement therapy: AICAR, an analog of AMP, increases SOX2 expression and promotes innate immunity against bacterial infection, 6/April/2015, 17.32, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How AICAR (1) increases the expression of Sox2; and (2) promotes bacterial resistance.