Mechanistic insight into tumorigenesis: Apolipoprotein E (apoE) decreases the expression of tumor suppressor PTEN via up regulation of its target gene, 28/April/2015, 23.07

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Mechanistic insight into tumorigenesis: Apolipoprotein E (apoE) decreases the expression of tumor suppressor PTEN via up regulation of its target gene, 28/April/2015, 23.07, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: This study suggests, for the first time, that Apolipoprotein E (apoE), by increasing the expression of its target gene, it may decrease the expression of PTEN. Thereby, it may promote tumorigensis.  Thus, pharmacological formulations encompassing “Apolipoprotein E (apoE) inhibitors” can be used to inhibit tumor progresssion.

Undisclosed information: How Apolipoprotein E (apoE)  decreases the expression of PTEN 

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