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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., MiRNA-based anti-metastasis therapy: MiRNA-139 decreases the expression of PD-1, a suppressor of activation of T-cells, and activates the immune system via down regulation of its target gene, 29/April/2015, 7.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that MiRNA-139, by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate the immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing MiRNA-139 activators may be used to inhibit the progression of tumors.

Undisclosed information: How  MiRNA-139 suppresses the expression of PD-1

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