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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Natural product-based Lifespan extension therapy: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 1/April/2014, 22.03, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that Piceatannol, by increasing the expression of its target gene,  it may suppress the expression of AT1R. And thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Piceatannol or its analogues” may be used to extend the life-span of an individual.

Undisclosed information: How Piceatannol suppresses the expression of  angiotensin II type I receptor (AT1R)

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