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A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells. This study was published in the August 7  2014 Cell Stem Cell (the number 1 journal in “Stem cell biology” with an impact factor of 23.563) by Prof Axel Behrens, Rocio Sancho, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based Regenerative therapy for T2D: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), promotes  reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3. This study suggests that Piceatannol, by increasing the expression of Ngn3 in adult pancreatic ductal cells, it may reprogram adult pancreatic ductal cells into β cells. Thereby, it may induce the expression of Ngn3, increase insulin secretion and inhibit insulin resistance. Together, this study suggests that pharmacological formulations encompassing “Piceatannol or its analogues” may be used to regenerate  β cells in T2D patients. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based Regenerative therapy for T2D: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), promotes  reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 27/April/2015, 22.18,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Piceatannol increases the expression of Ngn3

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