Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Hibiscus extract increases the expression of ERBB2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 22/April/2014, 7.40 am

Natural product-based Lifespan extension therapy: 3-caffeoyl, 4-dihydrocaffeoylquinic acid (CDCQ) may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 22/April/2014, 7.34 am
April 22, 2015
Regenerative therapy for Diabetes mellitus: MTA1 increases human pancreatic beta cell replication via down regulation of its target gene DYRK1A, 22/April/2015, 8.59 am
April 22, 2015
Show all

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor ED’Uva G, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Hibiscus extract increases the expression of ERBB2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene

Significance: 

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and were expected to be doubled by 2015; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients.

This study suggests, for the first time, a Natural product-based cardiac regeneration therapy. Hibiscus extract, by decreasing the expression of its target gene, it may: (1) increase ERBB2 expression; and (2) induce cardiomycyte regeneration.  Thus, pharmacological formulations encompassing Hibiscus extract or small molecule compounds isolated from it” may be used to promote cardiomyocyte regeneration following myocardial infarction

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Hibiscus extract increases the expression of ERBB2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 22/April/2014,  7.39 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Undisclosed information: How Hibiscus extract increases the expression of  ERBB2

Comments are closed.