Regenerative therapy for DM: Inhibitor of differentiation-4 (Id4) promotes an insulin-sensitized state via up regulation of reprogramming protein Lin28, 1/April/2015, 7.45 am

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A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” [I.F: 33.116]  by Prof Daley GQ, Zhu H, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative therapy for DM: Inhibitor of differentiation-4 (Id4) promotes an insulin-sensitized state via up regulation of reprogramming protein Lin28

Significance: Prof. Daley GQ and his team members have shown that loss of Lin28 promotes insulin resistance and glucose intolerance. The study presented here suggests, for the first time, that  Id4, by increasing the expression of its target gene, it may increase the expression of RNA-binding protein Lin-28, and thereby promote insulin sensitivity. Thus, pharmacological formulations encompassing ” Id4 activators” may be used to treat DM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed information: How  Id4 increases the expression of Lin28

To citeBoominathan, Regenerative therapy for DM: Inhibitor of differentiation-4 (Id4) promotes an insulin sensitized state via up regulation of reprogramming protein Lin28, 1/April/2015, 7.45 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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