Small molecule-based Life-span extension therapy: AICAR, an analog of AMP, inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 6/April/2015, 17.41

Immune enhancement therapy: AICAR, an analog of AMP, increases SOX2 expression and promotes innate immunity against bacterial infection, 6/April/2015, 17.33
April 6, 2015
Natural product-based therapy for p53-deficient tumors: Asprin [acetylsalicylic acid (ASA)] suppresses and increases the expression of DNp63α and IAPP(Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 6/April/2015, 22.38
April 6, 2015
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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Life-span extension therapy: AICAR, an analog of AMP, inhibits senescence and  extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 6/April/2015, 17.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests, for the first time, that AICAR, by decreasing the expression of its target gene,  it may suppress the expression of ADCY5/AC5. Thereby, it may extend the lifespan of an individual. Thus, pharmacological formulations encompassing AICAR or its analogues may be used to extend the life-span of an an individual.

Undisclosed information: How AICAR suppresses the expression of  adenylate cyclase 5 (ADCY5)

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