Small molecule-based Life-span extension therapy: Orphan nuclear receptor NUR77 inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 20/April/2015, 15.57

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Life-span extension therapy: Orphan nuclear receptor NUR77 inhibits senescence and  extends life span by down regulating the expression of  adenylate cyclase 5 (ADCY5), 20/April/2015, 15.56, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests, for the first time, that NUR77, by increasing the expression of its target gene,  it may suppress the expression of ADCY5/AC5. Thereby, it may extend the lifespan of an individual. Thus, pharmacological formulations encompassing NUR77 activators may be used to extend the life-span of an an individual.

Undisclosed information: How NUR77 suppresses the expression of  adenylate cyclase 5 (ADCY5)

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