Small molecule-based Lifespan extension therapy: 17β-E2(An estrogen derivative) may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/April/2014, 8.01 am

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Lifespan extension therapy:  17β-E2(An estrogen derivative) may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/April/2014, 8.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that  17β-E2, by increasing the expression of its target gene,  it may suppress the expression of AT1R. And thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing ” 17β-E2 or its analogues” may be used to extend the life-span of an individual.

Undisclosed information: How  17β-E2 suppresses the expression of  angiotensin II type I receptor (AT1R)

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