Small molecule-based Lifespan extension therapy: Exendin-4/Exenatide, a Glucagon-Like Protein-1 (GLP-1) Receptor Agonist, may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 13/April/2014, 11.14 am

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Small molecule-based Lifespan extension therapy: Exendin-4/Exenatide, a Glucagon-Like Protein-1 (GLP-1) Receptor Agonist, may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 13/April/2014, 11.14 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. Exendin-4/Exenatide is used in the treatment of diabetes mellitus type 2 (T2DM). This study suggests, for the first time, that  Exendin-4, by increasing the expression of its target gene,  it may suppress the expression of AT1R. And, thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing Exendin-4 or its analogues may be used to extend the life-span of an individual.

Undisclosed information: How Exendin-4 suppresses the expression of  angiotensin II type I receptor (AT1R)

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