Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: Leucine may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 12/April/2014, 23.35, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been shown earlier that angiotensin II type I receptor (AT1R) antagonist prolongs mammalian life span. This study suggests, for the first time, that Leucine, by increasing the expression of its target gene, it may suppress the expression of AT1R. And thereby, it may (1) decrease blood pressure; and (2) and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Leucine or its analogues” may be used to extend the life-span of an individual.
Undisclosed information: How Leucine suppresses the expression of angiotensin II type I receptor (AT1R)