Small RNA-based Lifespan extension therapy: MiRNA-200a promotes cellular fitness and extends life span via down regulation of its target gene, 28/April/2014, 14.48

Exercise training ameliorates T2DM & extends lifespan: Exercise training increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene, 28/April/2015, 9.46 am
April 28, 2015
MiRNA-based therapy for leukaemia: MiRNA-24-1 suppresess B-cell lineage acute lymphoid leukaemia via down regulation of its target gene, 28/April/2014, 15.00
April 28, 2015
Show all

A recent study from the Department of Biology, McGill University, H3A 1B1, Montreal, Quebec, Canada shows that “Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.” This study was published in the 15 October  2005 issue of the journal “Genes & Development” (Impact factor: 12.44) by Prof Hekimi SLiu X, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small RNA-based Lifespan extension therapy: MiRNA-495 promotes cellular fitness and life span via down regulation of its target gene

Significance: 

This study suggests, for the first time, a small RNA-based Lifespan extension therapy. MiRNA-200a, by decreasing the expression of its target gene mclk1, it may:(1) increase cellular fitness; and (2) extend lifespan.  Thus, pharmacological formulations encompassing MiRNA-200a or its activators may be used to increase cellular fitness; and extend lifespan.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, Small RNA-based Lifespan extension therapy: MiRNA-200a promotes cellular fitness and extends life span via down regulation of its target gene, 28/April/2014, 14.48,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.